Outside Publication

Applied Biophysics for Drug Discovery, Wiley

September 2017

Associate Donald Huddler editedApplied Biophysics for Drug Discovery, a guide to new techniques and approaches to identifying and characterizing small molecules in early drug discovery.

Biophysical methods are reasserting their utility in drug discovery and through a combination of the rise of fragment-based drug discovery and an increased focus on more nuanced characterisation of small molecule binding, these methods are playing an increasing role in discovery campaigns.

This text emphasizes practical considerations for selecting and deploying core biophysical method, including but not limited to ITC, SPR, and both ligand-detected and protein-detected NMR. It is ideal for academic investigators and industry scientists planning hit characterization campaigns or designing and optimizing screening strategies.

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