Proposed reforms to patent subject matter eligibility in the United States are once again making headlines. With advancements in medical device technologies and the increasing integration of software, patent eligibility considerations implicate a growing realm of medical devices. In a recent LawFlash, we address a draft bill in the US Congress that could broaden the range of patent eligible subject matter with implications for stronger commercialization of medical device technologies in the United States. We also discuss two recent letters to the US Senate that crystalize the growing debate over expanding patent eligibility with possible effects on medical device innovation, affordability, and availability.