Co-author, A New and Efficient Synthetic Route for the Anxiolytic Agent CL285032, Bioorganic & Medicinal Chemistry Letters, Volume 21, Issue 1

CL285032 is an anxiolytic compound currently under investigation as a possible treatment for canine noise phobia associated anxiety. A robust scale-up and manufacturing process is essential for the development and marketability of the drug. The current synthetic route, although reliable, requires seven steps and has a low overall yield (18%), leaving opportunity for improvement. We are presenting an efficient alternative approach toward the synthesis of CL285032 and the results thereof.